Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations

The allele frequency net database (http://www .allelefrequencies.net) is an online repository that contains information on the frequencies of immune genes and their corresponding alleles in different populations. The extensive variability observed in genes and alleles related to the immune system response and its significance in transplantation, disease association studies and diversity in populations led to the development of this electronic resource. At present, the system contains data from 1133 populations in 608 813 individuals on the frequency of genes from different polymorphic regions such as human leukocyte antigens, killer-cell immunoglobulin-like receptors, major histocompatibility complex Class I chainrelated genes and a number of cytokine gene polymorphisms. The project was designed to create a central source for the storage of frequency data and provide individuals with a set of bioinformatics tools to analyze the occurrence of these variants in worldwide populations. Th...

• Type: Journal
• Year: 2011
• Where: NAR
• Authors: Faviel F. Gonzalez-Galarza, Stephen Christmas, Derek Middleton, Andrew R. Jones
• Keywords: Immune System Response, NAR 2011, Population Genetics, Worldwide Populations