—Network coding aware routing protocols have been an interesting research topic in recent years. In this paper, we explore similar routing gains with physical layer coding techniques. A source routing protocol S3 is proposed to be implemented with a routing metric called iETT. By extending the traditional ETT measurement, iETT provides a simple way to make the routing protocol interference-aware. To further enable superposition coding and successive interference cancellation, S3 uses iETT to explore physical layer coding opportunities and measure potential gains in network throughput. Experimental evaluations confirm the effectiveness of iETT and S3. Significant improvements in network throughput are observed in both singlepath and multi-path routing scenarios.