High-end biomedical applications are a good target for specificpurpose system-on-chip (SoC) implementations. Human heart electrocardiogram (ECG) real-time monitoring and analysis is an immediate example with a large potential market. Today, the lack of scalable hardware platforms limits real-time analysis capabilities of most portable ECG analyzers, and prevents the upgrade of analysis algorithms for better accuracy. Multiprocessor system-on-chip (MPSoC) technology, which is becoming main-stream in the domain of high-performance microprocessors, is becoming attractive even for powerconstrained portable applications, due to the capability to provide scalable computation horsepower at an affordable power cost. This paper illustrates one of the first comprehensive HW/SW exploration frameworks to fully exploit MPSoC technology to improve the quality of real-time ECG analysis. Categories and Subject Descriptors C.3 [Special-Purpose and Application-Based Systems]: Microprocessor/microcomput...