Local protein structure prediction using discriminative models

Background: In recent years protein structure prediction methods using local structure information have shown promising improvements. The quality of new fold predictions has risen significantly and in fold recognition incorporation of local structure predictions led to improvements in the accuracy of results. We developed a local structure prediction method to be integrated into either fold recognition or new fold prediction methods. For each local sequence window of a protein sequence the method predicts probability estimates for the sequence to attain particular local structures from a set of predefined local structure candidates. The first step is to define a set of local structure representatives based on clustering recurrent local structures. In the second step a discriminative model is trained to predict the local structure representative given local sequence information.

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Oliver Sander, Ingolf Sommer, Thomas Lengauer
• Keywords: BMCBI 2006, Local Structure, Prediction, Structure Prediction