MetaQTL: a package of new computational methods for the meta-analysis of QTL mapping experiments

Background: Integration of multiple results from Quantitative Trait Loci (QTL) studies is a key point to understand the genetic determinism of complex traits. Up to now many efforts have been made by public database developers to facilitate the storage, compilation and visualization of multiple QTL mapping experiment results. However, studying the congruency between these results still remains a complex task. Presently, the few computational and statistical frameworks to do so are mainly based on empirical methods (e.g. consensus genetic maps are generally built by iterative projection). Results: In this article, we present a new computational and statistical package, called MetaQTL, for carrying out whole-genome meta-analysis of QTL mapping experiments. Contrary to existing methods, MetaQTL offers a complete statistical process to establish a consensus model for both the marker and the QTL positions on the whole genome. First, MetaQTL implements a new statistical approach to merge mu...

• Type: Journal
• Year: 2007
• Where: BMCBI
• Authors: Jean-Baptiste Veyrieras, Bruno Goffinet, Alain Charcosset
• Keywords: BMCBI 2007, Multiple Qtl, Observed Qtl, QTL Location