Recent developments in E-Learning systems aim at providing a better support for didactics-aware learning scenarios. Typically, in order to provide that support the number and complexity of the system features must be increased. Consequently, maintaining or configuring of such systems becomes increasingly difficult. In this paper an ontology-based solution for automatic configuration of the system features according to didactically sound descriptions of learning scenarios is proposed. Additionally, a possible application of the proposed solution in a collaborative E-Learning system called WBT-Master is presented.