PathFinder: mining signal transduction pathway segments from protein-protein interaction networks

Background: A Signal transduction pathway is the chain of processes by which a cell converts an extracellular signal into a response. In most unicellular organisms, the number of signal transduction pathways influences the number of ways the cell can react and respond to the environment. Discovering signal transduction pathways is an arduous problem, even with the use of systematic genomic, proteomic and metabolomic technologies. These techniques lead to an enormous amount of data and how to interpret and process this data becomes a challenging computational problem. Results: In this study we present a new framework for identifying signaling pathways in proteinprotein interaction networks. Our goal is to find biologically significant pathway segments in a given interaction network. Currently, protein-protein interaction data has excessive amount of noise, e.g., false positive and false negative interactions. First, we eliminate false positives in the proteinprotein interaction network...

• Type: Journal
• Year: 2007
• Where: BMCBI
• Authors: Gürkan Bebek, Jiong Yang
• Keywords: BMCBI 2007, Signal Transduction, Signal Transduction Pathways, Transduction Pathways