Petri Net Based Model Of The T Cell Receptor Signaling Pathway

Intracellular signaling pathways as well as the interactions and coordination that exist among them are complex and difficult to visualize and understand. Computer-based models of such pathways can aid in understanding the mechanics of their operation. Such models allow the display and manipulation of the network of interacting components. Simulations that run on the constructed model emulate the dynamics of the modeled process. This allows the simultaneous interplay of the represented variables to be observed and analyzed, thus facilitating an understanding of the modeled process. The modeling of such pathways is the focus of this work. In particular, we have focused on creating an executable Petri net model of the T Cell Receptor (TCR) mediated signaling pathway. This pathway is a critical part of the body's defense mechanism against infectious agents. The model depicts the pathway in terms of the elements involved and events that occur.

• Type: Conference
• Year: 2006
• Where: BIOCOMP
• Authors: Srinidhi Jayasuryan, Anil Bamezai, Vijay Gehlot
• Keywords: BIOCOMP 2006, BIOCOMP 2007, Intracellular Signaling Pathways, Modeled Process, Signaling Pathway