Recognition of interferon-inducible sites, promoters, and enhancers

Background: Computational analysis of gene regulatory regions is important for prediction of functions of many uncharacterized genes. With this in mind, search of the target genes for interferon (IFN) induction appears of interest. IFNs are multi-functional cytokines. Their effects are immunomodulatory, antiviral, antibacterial, and antitumor. The interaction of the IFNs with their cell surface receptors produces an activation of several transcription factors. Four regulatory factors, ISGF3, STAT1, IRF1, and NF-κB, are essential for the function of the IFN system. The aim of this work is the development of computational approaches for the recognition of DNA binding sites for these factors and computer programs for the prediction of the IFN-inducible regions. Results: We developed computational approaches to the recognition of the binding sites for ISGF3, STAT1, IRF1, and NF-κB. Analysis of the distribution of these binding sites demonstrated that the regions -500 upstream of the tra...

• Type: Journal
• Year: 2007
• Where: BMCBI
• Authors: Elena A. Ananko, Yury V. Kondrakhin, Tatyana I. Merkulova, Nikolay A. Kolchanov
• Keywords: Binding Sites, BMCBI 2007, Computational Approaches, IFN-inducible Genes