SCOWLP classification: Structural comparison and analysis of protein binding regions

Background: Detailed information about protein interactions is critical for our understanding of the principles governing protein recognition mechanisms. The structures of many proteins have been experimentally determined in complex with different ligands bound either in the same or different binding regions. Thus, the structural interactome requires the development of tools to classify protein binding regions. A proper classification may provide a general view of the regions that a protein uses to bind others and also facilitate a detailed comparative analysis of the interacting information for specific protein binding regions at atomic level. Such classification might be of potential use for deciphering protein interaction networks, understanding protein function, rational engineering and design. Description: Protein binding regions (PBRs) might be ideally described as well-defined separated regions that share no interacting residues one another. However, PBRs are often irregular, d...

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Joan Teyra, Maciej Paszkowski-Rogacz, Gerd Anders, M. Teresa Pisabarro
• Keywords: Binding Regions, BMCBI 2008, Protein, Protein Binding Regions