Synchronization and Oscillatory Dynamics in Heterogeneous, Mutually Inhibited Neurons

Abstract. We study some mechanisms responsible for synchronous oscillations and loss of synchrony at physiologically relevant frequencies 10-200 Hz in a network of heterogeneous inhibitory neurons. We focus on the factors that determine the level of synchrony and frequency of the network response, as well as the e ects of mild heterogeneity on network dynamics. With mild heterogeneity, synchrony is never perfect and is relatively fragile. In addition, the e ects of inhibition are more complex in mildly heterogeneous networks than in homogeneous ones. In the former, synchrony is broken in two distinct ways, depending on the ratio of the synaptic decay time to the period of repetitive action potentials  s=T, where T can be determined either from the network or from a single, self-inhibiting neuron. With s=T 2, corresponding to large applied current, small synaptic strength or large synaptic decay time, the e ects of inhibition are largely tonic and heterogeneous neurons spike relativ...

• Type: Journal
• Year: 1998
• Where: JCNS
• Authors: John A. White, Carson C. Chow, Jason Ritt, Cristina Soto-Treviño, Nancy Kopell
• Keywords: Heterogeneous Inhibitory Neurons, JCNS 1998, Mild Heterogeneity, Synchrony