Versatile annotation and publication quality visualization of protein complexes using POLYVIEW-3D

Background: Macromolecular visualization as well as automated structural and functional annotation tools play an increasingly important role in the post-genomic era, contributing significantly towards the understanding of molecular systems and processes. For example, three dimensional (3D) models help in exploring protein active sites and functional hot spots that can be targeted in drug design. Automated annotation and visualization pipelines can also reveal other functionally important attributes of macromolecules. These goals are dependent on the availability of advanced tools that integrate better the existing databases, annotation servers and other resources with state-of-the-art rendering programs. Results: We present a new tool for protein structure analysis, with the focus on annotation and visualization of protein complexes, which is an extension of our previously developed POLYVIEW web server. By integrating the web technology with state-of-the-art software for macromolecula...

• Type: Journal
• Year: 2007
• Where: BMCBI
• Authors: Aleksey A. Porollo, Jaroslaw Meller
• Keywords: Annotation, BMCBI 2007, Functional Annotations, Macromolecular Visualization