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BMCBI
2008
13 years 9 months ago
2008
Background: A major obstacle in treatment of HIV is the ability of the virus to mutate rapidly into drug-resistant variants. A method for predicting the susceptibility of mutated ...
BMCBI
2007
13 years 9 months ago
2007
Background: During the past decades, research and development in drug discovery have attracted much attention and efforts. However, only 324 drug targets are known for clinical dr...
BMCBI
2008
13 years 9 months ago
2008
Background: Virtual or in silico ligand screening combined with other computational methods is one of the most promising methods to search for new lead compounds, thereby greatly ...
BMCBI
2007
13 years 9 months ago
2007
Background: Selecting the highest quality 3D model of a protein structure from a number of alternatives remains an important challenge in the field of structural bioinformatics. M...
BMCBI
2010
13 years 9 months ago
2010
Background: Immunoglobulin (IG or antibody) and the T-cell receptor (TR) are pivotal proteins in the immune system of higher organisms. In cancer immunotherapy, the immune respons...