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BMCBI
2006
110views more  BMCBI 2006»
13 years 10 months ago
Design of a combinatorial DNA microarray for protein-DNA interaction studies
Background: Discovery of precise specificity of transcription factors is an important step on the way to understanding the complex mechanisms of gene regulation in eukaryotes. Rec...
Julian Mintseris, Michael B. Eisen
RECOMB
2004
Springer
14 years 3 months ago
Application of Kernel Method to Reveal Subtypes of TF Binding Motifs
Transcription factor binding sites often contain several subtypes of sequences that follow not just one but several different patterns. We developed a novel sensitive method based ...
Alexander E. Kel, Yuri Tikunov, Nico Voss, Jü...
BMCBI
2006
87views more  BMCBI 2006»
13 years 10 months ago
Phylogeny based discovery of regulatory elements
Background: Algorithms that locate evolutionarily conserved sequences have become powerful tools for finding functional DNA elements, including transcription factor binding sites;...
Jason Gertz, Justin C. Fay, Barak A. Cohen
GECCO
2005
Springer
140views Optimization» more  GECCO 2005»
14 years 3 months ago
MDGA: motif discovery using a genetic algorithm
Computationally identifying transcription factor binding sites in the promoter regions of genes is an important problem in computational biology and has been under intensive resea...
Dongsheng Che, Yinglei Song, Khaled Rasheed
BMCBI
2007
145views more  BMCBI 2007»
13 years 10 months ago
Improved benchmarks for computational motif discovery
Background: An important step in annotation of sequenced genomes is the identification of transcription factor binding sites. More than a hundred different computational methods h...
Geir Kjetil Sandve, Osman Abul, Vegard Walseng, Fi...