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BMCBI
2006
119views more  BMCBI 2006»
13 years 6 months ago
LS-NMF: A modified non-negative matrix factorization algorithm utilizing uncertainty estimates
Background: Non-negative matrix factorisation (NMF), a machine learning algorithm, has been applied to the analysis of microarray data. A key feature of NMF is the ability to iden...
Guoli Wang, Andrew V. Kossenkov, Michael F. Ochs
BMCBI
2006
116views more  BMCBI 2006»
13 years 6 months ago
Gene annotation and network inference by phylogenetic profiling
Background: Phylogenetic analysis is emerging as one of the most informative computational methods for the annotation of genes and identification of evolutionary modules of functi...
Jie Wu, Zhenjun Hu, Charles DeLisi
BMCBI
2007
120views more  BMCBI 2007»
13 years 6 months ago
Quantitative sequence-function relationships in proteins based on gene ontology
Background: The relationship between divergence of amino-acid sequence and divergence of function among homologous proteins is complex. The assumption that homologs share function...
Vineet Sangar, Daniel J. Blankenberg, Naomi Altman...
JEA
2008
97views more  JEA 2008»
13 years 6 months ago
Approximating the true evolutionary distance between two genomes
As more and more genomes are sequenced, evolutionary biologists are becoming increasingly interested in evolution at the level of whole genomes, in scenarios in which the genome e...
Krister M. Swenson, Mark Marron, Joel V. Earnest-D...
ECCC
2007
86views more  ECCC 2007»
13 years 6 months ago
Testing Halfspaces
This paper addresses the problem of testing whether a Boolean-valued function f is a halfspace, i.e. a function of the form f(x) = sgn(w·x−θ). We consider halfspaces over the ...
Kevin Matulef, Ryan O'Donnell, Ronitt Rubinfeld, R...