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CSB
2005
IEEE
110views Bioinformatics» more  CSB 2005»
14 years 20 days ago
A Topological Measurement for Weighted Protein Interaction Network
High-throughput methods for detecting protein-protein interactions (PPI) have given researchers an initial global picture of protein interactions on a genomic scale. The usefulnes...
Pengjun Pei, Aidong Zhang
BMCBI
2010
120views more  BMCBI 2010»
13 years 7 months ago
Examination of the relationship between essential genes in PPI network and hub proteins in reverse nearest neighbor topology
Background: In many protein-protein interaction (PPI) networks, densely connected hub proteins are more likely to be essential proteins. This is referred to as the "centralit...
Kang Ning, Hoong Kee Ng, Sriganesh Srihari, Hon Wa...
BIBE
2005
IEEE
154views Bioinformatics» more  BIBE 2005»
14 years 21 days ago
Effective Pre-Processing Strategies for Functional Clustering of a Protein-Protein Interactions Network
In this article we present novel preprocessing techniques, based on topological measures of the network, to identify clusters of proteins from Protein-protein interaction (PPI) ne...
Duygu Ucar, Srinivasan Parthasarathy, Sitaram Asur...
BMCBI
2007
90views more  BMCBI 2007»
13 years 7 months ago
Gene network interconnectedness and the generalized topological overlap measure
Background: Network methods are increasingly used to represent the interactions of genes and/ or proteins. Genes or proteins that are directly linked may have a similar biological...
Andy M. Yip, Steve Horvath
BMCBI
2008
78views more  BMCBI 2008»
13 years 7 months ago
Deducing topology of protein-protein interaction networks from experimentally measured sub-networks
Background: Protein-protein interaction networks are commonly sampled using yeast two hybrid approaches. However, whether topological information reaped from these experimentallym...
Ling Yang, Thomas M. Vondriska, Zhangang Han, W. R...