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» A framework for protein and membrane interactions
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BMCBI
2007
166views more  BMCBI 2007»
13 years 8 months ago
PathFinder: mining signal transduction pathway segments from protein-protein interaction networks
Background: A Signal transduction pathway is the chain of processes by which a cell converts an extracellular signal into a response. In most unicellular organisms, the number of ...
Gürkan Bebek, Jiong Yang
BMCBI
2008
118views more  BMCBI 2008»
13 years 8 months ago
Drug interaction prediction using ontology-driven hypothetical assertion framework for pathway generation followed by numerical
Background: In accordance with the increasing amount of information concerning individual differences in drug response and molecular interaction, the role of in silico prediction ...
Takeshi Arikuma, Sumi Yoshikawa, Ryuzo Azuma, Kent...
JSW
2008
145views more  JSW 2008»
13 years 7 months ago
Analysis and Visualization of Gene Expressions and Protein Structures
This paper describes a web-based interactive framework for the analysis and visualization of gene expressions and protein structures. The formulation of the proposed framework was ...
Ashraf S. Hussein
BMCBI
2007
130views more  BMCBI 2007»
13 years 8 months ago
A model-based optimization framework for the inference of regulatory interactions using time-course DNA microarray expression da
Background: Proteins are the primary regulatory agents of transcription even though mRNA expression data alone, from systems like DNA microarrays, are widely used. In addition, th...
Reuben Thomas, Carlos J. Paredes, Sanjay Mehrotra,...
ICCS
2007
Springer
14 years 2 months ago
A Multiscale, Cell-Based Framework for Modeling Cancer Development
We use a systems approach to develop a predictive model that medical researchers can use to study and treat cancerous tumors. Our multiscale, cell-based model includes intracellula...
Yi Jiang