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» A graphical model for predicting protein molecular function
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ROCAI
2004
Springer
15 years 10 months ago
Learning Mixtures of Localized Rules by Maximizing the Area Under the ROC Curve
We introduce a model class for statistical learning which is based on mixtures of propositional rules. In our mixture model, the weight of a rule is not uniform over the entire ins...
Tobias Sing, Niko Beerenwinkel, Thomas Lengauer
BMCBI
2007
159views more  BMCBI 2007»
15 years 5 months ago
Computational genes: a tool for molecular diagnosis and therapy of aberrant mutational phenotype
Background: A finite state machine manipulating information-carrying DNA strands can be used to perform autonomous molecular-scale computations at the cellular level. Results: We ...
Israel Mark Martínez-Pérez, Gong Zha...
BMCBI
2010
118views more  BMCBI 2010»
15 years 5 months ago
Computing H/D-Exchange rates of single residues from data of proteolytic fragments
Background: Protein conformation and protein/protein interaction can be elucidated by solution-phase Hydrogen/ Deuterium exchange (sHDX) coupled to high-resolution mass analysis o...
Ernst Althaus, Stefan Canzar, Carsten Ehrler, Mark...
BIOINFORMATICS
2011
14 years 9 months ago
A method for probing the mutational landscape of amyloid structure
Motivation: Proteins of all kinds can self-assemble into highly ordered β-sheet aggregates known as amyloid fibrils, important both biologically and clinically. However, the spe...
Charles W. O'Donnell, Jérôme Waldisp&...
BMCBI
2005
143views more  BMCBI 2005»
15 years 5 months ago
Evaluation of BioCreAtIvE assessment of task 2
Background: Molecular Biology accumulated substantial amounts of data concerning functions of genes and proteins. Information relating to functional descriptions is generally extr...
Christian Blaschke, Eduardo Andrés Le&oacut...