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BMCBI
2011
13 years 2 months ago
Pathway-based analysis using reduced gene subsets in genome-wide association studies
Background: Single Nucleotide Polymorphism (SNP) analysis only captures a small proportion of associated genetic variants in Genome-Wide Association Studies (GWAS) partly due to s...
Jingyuan Zhao, Simone Gupta, Mark Seielstad, Jianj...
BIOCOMP
2006
13 years 8 months ago
Finding Molecular Signature of Prostate Cancer: An Algorithmic Approach
123 African American men in America are 65% more likely to develop prostate cancer and are two to three times more likely to die of the disease than Caucasian men [1]. While resear...
Patrick Bobbie, Renee Reams, Sandra Suther, C. Per...
SIGMOD
2004
ACM
142views Database» more  SIGMOD 2004»
14 years 7 months ago
Conditional Selectivity for Statistics on Query Expressions
Cardinality estimation during query optimization relies on simplifying assumptions that usually do not hold in practice. To diminish the impact of inaccurate estimates during opti...
Nicolas Bruno, Surajit Chaudhuri
BMCBI
2008
195views more  BMCBI 2008»
13 years 7 months ago
Goldsurfer2 (Gs2): A comprehensive tool for the analysis and visualization of genome wide association studies
Background: Genome wide association (GWA) studies are now being widely undertaken aiming to find the link between genetic variations and common diseases. Ideally, a well-powered G...
Fredrik Pettersson, Andrew P. Morris, Michael R. B...
BMCBI
2006
169views more  BMCBI 2006»
13 years 7 months ago
Comparative analysis of haplotype association mapping algorithms
Background: Finding the genetic causes of quantitative traits is a complex and difficult task. Classical methods for mapping quantitative trail loci (QTL) in miceuse an F2 cross b...
Phillip McClurg, Mathew T. Pletcher, Tim Wiltshire...