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» Adaptive Modeling of Biochemical Pathways
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BMCBI
2007
179views more  BMCBI 2007»
13 years 7 months ago
Automated smoother for the numerical decoupling of dynamics models
Background: Structure identification of dynamic models for complex biological systems is the cornerstone of their reverse engineering. Biochemical Systems Theory (BST) offers a pa...
Marco Vilela, Carlos Cristiano H. Borges, Susana V...
CORR
2010
Springer
139views Education» more  CORR 2010»
13 years 7 months ago
Information Fusion for Anomaly Detection with the Dendritic Cell Algorithm
Dendritic cells are antigen presenting cells that provide a vital link between the innate and adaptive immune system, providing the initial detection of pathogenic invaders. Resea...
Julie Greensmith, Uwe Aickelin, Gianni Tedesco
BMCBI
2007
173views more  BMCBI 2007»
13 years 7 months ago
Predicting state transitions in the transcriptome and metabolome using a linear dynamical system model
Background: Modelling of time series data should not be an approximation of input data profiles, but rather be able to detect and evaluate dynamical changes in the time series dat...
Ryoko Morioka, Shigehiko Kanaya, Masami Y. Hirai, ...
CSB
2003
IEEE
130views Bioinformatics» more  CSB 2003»
14 years 24 days ago
A Computational Approach to Reconstructing Gene Regulatory Networks
Reverse-engineering of gene networks using linear models often results in an underdetermined system because of excessive unknown parameters. In addition, the practical utility of ...
Xutao Deng, Hesham H. Ali
GECCO
2006
Springer
191views Optimization» more  GECCO 2006»
13 years 11 months ago
Automating the drug scheduling with different toxicity clearance in cancer chemotherapy via evolutionary computation
The toxicity of an anticancer drug is cleared from the body by different processes, including saturable metabolic and nonsaturable renal-excretion pathways. According to the princ...
Yong Liang, Kwong-Sak Leung, Tony Shu Kam Mok