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BMCBI
2004
141views more  BMCBI 2004»
13 years 8 months ago
Estimates of statistical significance for comparison of individual positions in multiple sequence alignments
Background: Profile-based analysis of multiple sequence alignments (MSA) allows for accurate comparison of protein families. Here, we address the problems of detecting statistical...
Ruslan Sadreyev, Nick V. Grishin
BMCBI
2004
119views more  BMCBI 2004»
13 years 8 months ago
Genome SEGE: A database for 'intronless' genes in eukaryotic genomes
Background: A number of completely sequenced eukaryotic genome data are available in the public domain. Eukaryotic genes are either 'intron containing' or 'intronle...
Meena K. Sakharkar, Pandjassarame Kangueane
BMCBI
2004
115views more  BMCBI 2004»
13 years 8 months ago
An SVD-based comparison of nine whole eukaryotic genomes supports a coelomate rather than ecdysozoan lineage
Background: Eukaryotic whole genome sequences are accumulating at an impressive rate. Effective methods for comparing multiple whole eukaryotic genomes on a large scale are needed...
Gary W. Stuart, Michael W. Berry
BMCBI
2002
214views more  BMCBI 2002»
13 years 8 months ago
Automated modelling of signal transduction networks
Background: Intracellular signal transduction is achieved by networks of proteins and small molecules that transmit information from the cell surface to the nucleus, where they ul...
Martin Steffen, Allegra Petti, John Aach, Patrik D...
BMCBI
2002
126views more  BMCBI 2002»
13 years 8 months ago
RIO: Analyzing proteomes by automated phylogenomics using resampled inference of orthologs
Background: When analyzing protein sequences using sequence similarity searches, orthologous sequences (that diverged by speciation) are more reliable predictors of a new protein&...
Christian M. Zmasek, Sean R. Eddy
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