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BMCBI
2010
191views more  BMCBI 2010»
13 years 3 months ago
Molecular dynamics simulation studies and in vitro site directed mutagenesis of avian beta-defensin Apl_AvBD2
Background: Defensins comprise a group of antimicrobial peptides, widely recognized as important elements of the innate immune system in both animals and plants. Cationicity, rath...
Soja Saghar Soman, Krishnankutty Chandrika Sivakum...
BMCBI
2011
13 years 3 months ago
Systematic error detection in experimental high-throughput screening
Background: High-throughput screening (HTS) is a key part of the drug discovery process during which thousands of chemical compounds are screened and their activity levels measure...
Plamen Dragiev, Robert Nadon, Vladimir Makarenkov
BMCBI
2011
13 years 3 months ago
The impact of quantitative optimization of hybridization conditions on gene expression analysis
Background: With the growing availability of entire genome sequences, an increasing number of scientists can exploit oligonucleotide microarrays for genome-scale expression studie...
Peter Sykacek, David P. Kreil, Lisa A. Meadows, Ri...
CIKM
2010
Springer
13 years 3 months ago
Mining networks with shared items
Recent advances in data processing have enabled the generation of large and complex graphs. Many researchers have developed techniques to investigate informative structures within...
Jun Sese, Mio Seki, Mutsumi Fukuzaki
NAR
2011
227views Computer Vision» more  NAR 2011»
13 years 3 months ago
VnD: a structure-centric database of disease-related SNPs and drugs
Numerous genetic variations have been found to be related to human diseases. Significant portion of those affect the drug response as well by changing the protein structure and fu...
Jin Ok Yang, Sangho Oh, Gunhwan Ko, Seong-Jin Park...