VnD: a structure-centric database of disease-related SNPs and drugs

Numerous genetic variations have been found to be related to human diseases. Significant portion of those affect the drug response as well by changing the protein structure and function. Therefore, it is crucial to understand the trilateral relationship among genomic variations, diseases and drugs. We present the variations and drugs (VnD), a consolidated database containing information on diseases, related genes and genetic variations, protein structures and drug information. VnD was built in three steps. First, we integrated various resources systematically to deduce catalogs of disease-related genes, single nucleotide polymorphisms (SNPs), protein mutations and relevant drugs. VnD contains 137 195 diseaserelated gene records (13 940 distinct genes) and 16 586 genetic variation records (1790 distinct variations). Next, we carried out structure modeling and docking simulation for wild-type and mutant proteins to examine the structural and functional consequences of non-synonymous SNP...

• Type: Journal
• Year: 2011
• Where: NAR
• Authors: Jin Ok Yang, Sangho Oh, Gunhwan Ko, Seong-Jin Park, Woo-Yeon Kim, Byungwook Lee, Sanghyuk Lee
• Keywords: Computer Vision, Drugs, Genetic Variations, NAR 2011, Protein