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» Analysis of computational approaches for motif discovery
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ALMOB
2006
86views more  ALMOB 2006»
13 years 11 months ago
Analysis of computational approaches for motif discovery
Recently, we performed an assessment of 13 popular computational tools for discovery of transcription factor binding sites (M. Tompa, N. Li, et al., "Assessing Computational ...
Nan Li, Martin Tompa
IMSCCS
2006
IEEE
14 years 5 months ago
Combining Comparative Genomics with de novo Motif Discovery to Identify Human Transcription Factor DNA-Binding Motifs
Background: As more and more genomes are sequenced, comparative genomics approaches provide a methodology for identifying conserved regulatory elements that may be involved in gen...
Linyong Mao, W. Jim Zheng
GECCO
2005
Springer
124views Optimization» more  GECCO 2005»
14 years 4 months ago
The evolutionary computation approach to motif discovery in biological sequences
Finding motifs — patterns of conserved residues — within nucleotide and protein sequences is a key part of understanding function and regulation within biological systems. Thi...
Michael A. Lones, Andrew M. Tyrrell
BMCBI
2006
103views more  BMCBI 2006»
13 years 11 months ago
Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequili
Background: The discovery of cis-regulatory motifs still remains a challenging task even though the number of sequenced genomes is constantly growing. Computational analyses using...
Kenneth W. Berendzen, Kurt Stüber, Klaus Hart...
BMCBI
2002
128views more  BMCBI 2002»
13 years 10 months ago
Correlating overrepresented upstream motifs to gene expression: a computational approach to regulatory element discovery in euka
Background: Gene regulation in eukaryotes is mainly effected through transcription factors binding to rather short recognition motifs generally located upstream of the coding regi...
Michele Caselle, Ferdinando Di Cunto, Paolo Prover...