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BMCBI
2002
108views more  BMCBI 2002»
13 years 8 months ago
A memory-efficient dynamic programming algorithm for optimal alignment of a sequence to an RNA secondary structure
Background: Covariance models (CMs) are probabilistic models of RNA secondary structure, analogous to profile hidden Markov models of linear sequence. The dynamic programming algo...
Sean R. Eddy
BMCBI
2005
162views more  BMCBI 2005»
13 years 8 months ago
Accelerated probabilistic inference of RNA structure evolution
Background: Pairwise stochastic context-free grammars (Pair SCFGs) are powerful tools for evolutionary analysis of RNA, including simultaneous RNA sequence alignment and secondary...
Ian Holmes
BMCBI
2010
154views more  BMCBI 2010»
13 years 8 months ago
Fine-tuning structural RNA alignments in the twilight zone
Background: A widely used method to find conserved secondary structure in RNA is to first construct a multiple sequence alignment, and then fold the alignment, optimizing a score ...
Andreas Bremges, Stefanie Schirmer, Robert Giegeri...
NAR
1998
104views more  NAR 1998»
13 years 8 months ago
The ribonuclease P database
Ribonuclease P is the endoribonuclease responsible for the removal of leader sequences from tRNA precursors. Ribonuclease P is a ribonucleoprotein, and in bacteria the RNA alone i...
James W. Brown
AO
2011
112views more  AO 2011»
13 years 3 months ago
The RNA Ontology (RNAO): An ontology for integrating RNA sequence and structure data
Biomedical Ontologies are intended to integrate diverse biomedical data to enable intelligent datamining and facilitate translation of basic research into useful clinical knowledg...
Robert Hoehndorf, Colin R. Batchelor, Thomas Bittn...