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» Challenges of sequencing human genomes
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BMCBI
2007
120views more  BMCBI 2007»
13 years 8 months ago
Non-coding sequence retrieval system for comparative genomic analysis of gene regulatory elements
Background: Completion of the human genome sequence along with other species allows for greater understanding of the biochemical mechanisms and processes that govern healthy as we...
Sung Tae Doh, Yunyu Zhang, Matthew H. Temple, Li C...
BMCBI
2010
107views more  BMCBI 2010»
13 years 9 months ago
TagCleaner: Identification and removal of tag sequences from genomic and metagenomic datasets
Background: Sequencing metagenomes that were pre-amplified with primer-based methods requires the removal of the additional tag sequences from the datasets. The sequenced reads ca...
Robert Schmieder, Yan Wei Lim, Forest Rohwer, Robe...
BMCBI
2005
109views more  BMCBI 2005»
13 years 8 months ago
Genome comparison without alignment using shortest unique substrings
Background: Sequence comparison by alignment is a fundamental tool of molecular biology. In this paper we show how a number of sequence comparison tasks, including the detection o...
Bernhard Haubold, Nora Pierstorff, Friedrich M&oum...
BMCBI
2004
174views more  BMCBI 2004»
13 years 8 months ago
SeeGH - A software tool for visualization of whole genome array comparative genomic hybridization data
Background: Array comparative genomic hybridization (CGH) is a technique which detects copy number differences in DNA segments. Complete sequencing of the human genome and the dev...
Bryan Chi, Ronald J. deLeeuw, Bradley P. Coe, Calu...
RECOMB
2010
Springer
14 years 3 months ago
Genomic DNA k-mer Spectra: Models and Modalities
Background: The empirical frequencies of DNA k-mers in whole genome sequences provide an interesting perspective on genomic complexity, and the availability of large segments of g...
Benny Chor, David Horn, Nick Goldman, Yaron Levy, ...