SeeGH - A software tool for visualization of whole genome array comparative genomic hybridization data

Background: Array comparative genomic hybridization (CGH) is a technique which detects copy number differences in DNA segments. Complete sequencing of the human genome and the development of an array representing a tiling set of tens of thousands of DNA segments spanning the entire human genome has made high resolution copy number analysis throughout the genome possible. Since array CGH provides signal ratio for each DNA segment, visualization would require the reassembly of individual data points into chromosome profiles. Results: We have developed a visualization tool for displaying whole genome array CGH data in the context of chromosomal location. SeeGH is an application that translates spot signal ratio data from array CGH experiments to displays of high resolution chromosome profiles. Data is imported from a simple tab delimited text file obtained from standard microarray image analysis software. SeeGH processes the signal ratio data and graphically displays it in a conventional...

• Type: Journal
• Year: 2004
• Where: BMCBI
• Authors: Bryan Chi, Ronald J. deLeeuw, Bradley P. Coe, Calum MacAulay, Wan L. Lam
• Keywords: Array Cgh, Array Cgh Data, BMCBI 2004, Dna Segments