524 search results - page 35 / 105 » Challenges of sequencing human genomes |
BMCBI
2007
13 years 9 months ago
2007
Background: Sequence comparison faces new challenges today, with many complete genomes and large libraries of transcripts known. Gene annotation pipelines match these sequences in...
BMCBI
2007
13 years 9 months ago
2007
Background: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the mos...
BMCBI
2011
13 years 3 months ago
2011
Background: The number of gene sequences that are available for comparative genomics approaches is increasing extremely quickly. A current challenge is to be able to handle this h...
BMCBI
2006
13 years 9 months ago
2006
Background: Successful realization of a "systems biology" approach to analyzing cells is a grand challenge for our understanding of life. However, current modeling appro...
BMCBI
2007
13 years 9 months ago
2007
Background: Mitochondrial tRNAs have been the subject of study for structural biologists interested in their secondary structure characteristics, evolutionary biologists have rese...