A manually curated database of tetrapod mitochondrially encoded tRNA sequences and secondary structures

Background: Mitochondrial tRNAs have been the subject of study for structural biologists interested in their secondary structure characteristics, evolutionary biologists have researched patterns of compensatory and structural evolution and medical studies have been directed towards understanding the basis of human disease. However, an up to date, manually curated database of mitochondrially encoded tRNAs from higher animals is currently not available. Description: We obtained the complete mitochondrial sequence for 277 tetrapod species from GenBank and re-annotated all of the tRNAs based on a multiple alignment of each tRNA gene and secondary structure prediction made independently for each tRNA. The mitochondrial (mt) tRNA sequences and the secondary structure based multiple alignments are freely available as Supplemental Information online. Conclusion: We compiled a manually curated database of mitochondrially encoded tRNAs from tetrapods with completely sequenced genomes. In the co...

• Type: Journal
• Year: 2007
• Where: BMCBI
• Authors: Konstantin Yu Popadin, Leila A. Mamirova, Fyodor A. Kondrashov
• Keywords: BMCBI 2007, Mitochondrial, Mitochondrial Trnas, Secondary Structure