It is well known that the base composition along eukaryotic genomes is long-range correlated. Here, we investigate the effect of such long-range correlations on alignment score sta...
Philipp W. Messer, Ralf Bundschuh, Martin Vingron,...
Permutation of class labels is a common approach to build null distributions for significance analyis of microarray data. It is assumed to produce random score distributions, which...
Hidden Markov models (HMMs) have been successfully applied to a variety of problems in molecular biology, ranging from alignment problems to gene nding and annotation. Alignment p...
Biological macromoleculesrepresent a valuable source of informationfor the identification and phylogenetic classification of microorganisms.Oneof the mostcommonlyused macromolecul...
Henning Hermjakob, Robert Giegerich, Walter Arnold
The usual thermodynamicevaluation, based solely on the Standard Gibbs Energyof reaction, does not take into account the permissible ranges of concentrations of metabolites, and it...