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RECOMB
2006
Springer
16 years 4 months ago
Alignment Statistics for Long-Range Correlated Genomic Sequences
It is well known that the base composition along eukaryotic genomes is long-range correlated. Here, we investigate the effect of such long-range correlations on alignment score sta...
Philipp W. Messer, Ralf Bundschuh, Martin Vingron,...
RECOMB
2006
Springer
16 years 4 months ago
Permutation Filtering: A Novel Concept for Significance Analysis of Large-Scale Genomic Data
Permutation of class labels is a common approach to build null distributions for significance analyis of microarray data. It is assumed to produce random score distributions, which...
Stefanie Scheid, Rainer Spang
RECOMB
2001
Springer
16 years 4 months ago
Applications of generalized pair hidden Markov models to alignment and gene finding problems
Hidden Markov models (HMMs) have been successfully applied to a variety of problems in molecular biology, ranging from alignment problems to gene nding and annotation. Alignment p...
Lior Pachter, Marina Alexandersson, Simon Cawley
ISMB
1997
15 years 5 months ago
RIFLE: Rapid Identification of Microorganisms by Fragment Length Evaluation
Biological macromoleculesrepresent a valuable source of informationfor the identification and phylogenetic classification of microorganisms.Oneof the mostcommonlyused macromolecul...
Henning Hermjakob, Robert Giegerich, Walter Arnold
ISMB
1993
15 years 5 months ago
Identification of Localized and Distributed Bottlenecks in Metabolic Pathways
The usual thermodynamicevaluation, based solely on the Standard Gibbs Energyof reaction, does not take into account the permissible ranges of concentrations of metabolites, and it...
Michael L. Mavrovouniotis