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» Conservativity in Structured Ontologies
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WABI
2007
Springer
102views Bioinformatics» more  WABI 2007»
15 years 10 months ago
Homology Search with Fragmented Nucleic Acid Sequence Patterns
The comprehensive annotation of non-coding RNAs in newly sequenced genomes is still a largely unsolved problem because many functional RNAs exhibit not only poorly conserved sequen...
Axel Mosig, Julian J.-L. Chen, Peter F. Stadler
BMCBI
2007
102views more  BMCBI 2007»
15 years 4 months ago
Identification of homologs in insignificant blast hits by exploiting extrinsic gene properties
Background: Homology is a key concept in both evolutionary biology and genomics. Detection of homology is crucial in fields like the functional annotation of protein sequences and...
Jos Boekhorst, Berend Snel
BMCBI
2006
103views more  BMCBI 2006»
15 years 4 months ago
Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequili
Background: The discovery of cis-regulatory motifs still remains a challenging task even though the number of sequenced genomes is constantly growing. Computational analyses using...
Kenneth W. Berendzen, Kurt Stüber, Klaus Hart...
BMCBI
2006
117views more  BMCBI 2006»
15 years 4 months ago
SigFlux: A novel network feature to evaluate the importance of proteins in signal transduction networks
Background: Measuring each protein's importance in signaling networks helps to identify the crucial proteins in a cellular process, find the fragile portion of the biology sy...
Wei Liu, Dong Li, Jiyang Zhang, Yunping Zhu, Fuchu...
BMCBI
2007
164views more  BMCBI 2007»
15 years 4 months ago
SEARCHPATTOOL: a new method for mining the most specific frequent patterns for binding sites with application to prokaryotic DNA
Background: Computational methods to predict transcription factor binding sites (TFBS) based on exhaustive algorithms are guaranteed to find the best patterns but are often limite...
Fathi Elloumi, Martha Nason