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» Constraint Based Methods for Biological Sequence Analysis
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150
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BMCBI
2010
125views more  BMCBI 2010»
14 years 10 months ago
ProbFAST: Probabilistic Functional Analysis System Tool
Background: The post-genomic era has brought new challenges regarding the understanding of the organization and function of the human genome. Many of these challenges are centered...
Israel T. da Silva, Ricardo Z. N. Vêncio, Th...
157
Voted
BMCBI
2002
131views more  BMCBI 2002»
15 years 3 months ago
Efficient Boolean implementation of universal sequence maps (bUSM)
Background: Recently, Almeida and Vinga offered a new approach for the representation of arbitrary discrete sequences, referred to as Universal Sequence Maps (USM), and discussed ...
John Schwacke, Jonas S. Almeida
142
Voted
BMCBI
2006
145views more  BMCBI 2006»
15 years 3 months ago
Fast-Find: A novel computational approach to analyzing combinatorial motifs
Background: Many vital biological processes, including transcription and splicing, require a combination of short, degenerate sequence patterns, or motifs, adjacent to defined seq...
Micah Hamady, Erin Peden, Rob Knight, Ravinder Sin...
134
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SCFBM
2008
87views more  SCFBM 2008»
15 years 3 months ago
Analysis by siRNA_profile program displays novel thermodynamic characteristics of highly functional siRNA molecules
Objective: Here we report the improved results of a new siRNA design program and analysis tool called siRNA_profile that reveals an additional criterion for bioinformatic search o...
Pirkko Muhonen, Ranga N. Parthasarathy, Anthony J....
156
Voted
BMCBI
2005
134views more  BMCBI 2005»
15 years 3 months ago
Ancestral sequence alignment under optimal conditions
Background: Multiple genome alignment is an important problem in bioinformatics. An important subproblem used by many multiple alignment approaches is that of aligning two multipl...
Alexander K. Hudek, Daniel G. Brown 0001