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» Current approaches to gene regulatory network modelling
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BMCBI
2006
103views more  BMCBI 2006»
13 years 8 months ago
Probe-level linear model fitting and mixture modeling results in high accuracy detection of differential gene expression
Background: The identification of differentially expressed genes (DEGs) from Affymetrix GeneChips arrays is currently done by first computing expression levels from the low-level ...
Sébastien Lemieux
JGO
2011
89views more  JGO 2011»
12 years 11 months ago
Model building using bi-level optimization
Abstract In many problems from different disciplines such as engineering, physics, medicine, and biology, a series of experimental data is used in order to generate a model that ca...
Georges K. Saharidis, Ioannis P. Androulakis, Mari...
BMCBI
2007
247views more  BMCBI 2007»
13 years 8 months ago
A survey of DNA motif finding algorithms
Background: Unraveling the mechanisms that regulate gene expression is a major challenge in biology. An important task in this challenge is to identify regulatory elements, especi...
Modan K. Das, Ho-Kwok Dai
ICCS
2005
Springer
14 years 2 months ago
Phylogenetic Networks, Trees, and Clusters
Phylogenetic networks model evolutionary histories in the presence of non-treelike events such as hybrid speciation and horizontal gene transfer. In spite of their widely acknowled...
Luay Nakhleh, Li-San Wang
BMCBI
2008
120views more  BMCBI 2008»
13 years 8 months ago
A protein interaction based model for schizophrenia study
Background: Schizophrenia is a complex disease with multiple factors contributing to its pathogenesis. In addition to environmental factors, genetic factors may also increase susc...
Pei-Chun Hsu, Ueng-Cheng Yang, Kuan-Hui Shih, Chih...