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» Database Searching with DNA and Protein Sequences: An Introd...
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CIKM
2008
Springer
13 years 9 months ago
Pairwise statistical significance of local sequence alignment using multiple parameter sets
Background: Accurate estimation of statistical significance of a pairwise alignment is an important problem in sequence comparison. Recently, a comparative study of pairwise stati...
Ankit Agrawal, Xiaoqiu Huang
HICSS
2003
IEEE
166views Biometrics» more  HICSS 2003»
14 years 25 days ago
Comparative Genome Annotation for Mapping, Prediction and Discovery of Genes
We have used comparative genome analyses to produce annotated maps for large genomic loci. The first example is a locus on mouse chromosome 9 that is syntenic to human chromosome ...
Claudia Kappen, J. Michael Salbaum
BMCBI
2010
135views more  BMCBI 2010»
13 years 7 months ago
HDAPD: a web tool for searching the disease-associated protein structures
Background: The protein structures of the disease-associated proteins are important for proceeding with the structure-based drug design to against a particular disease. Up until n...
Yi-Ruen Lin, Hsin-Yuan Wei, Tsung-Lin Tsai, Thy-Ho...
BMCBI
2007
77views more  BMCBI 2007»
13 years 7 months ago
The reactive metabolite target protein database (TPDB) - a web-accessible resource
Background: The toxic effects of many simple organic compounds stem from their biotransformation to chemically reactive metabolites which bind covalently to cellular proteins. To ...
Robert P. Hanzlik, Yakov M. Koen, Bhargav Theertha...
BMCBI
2005
123views more  BMCBI 2005»
13 years 7 months ago
PSI-BLAST-ISS: an intermediate sequence search tool for estimation of the position-specific alignment reliability
Background: Protein sequence alignments have become indispensable for virtually any evolutionary, structural or functional study involving proteins. Modern sequence search and com...
Mindaugas Margelevicius, Ceslovas Venclovas