The reactive metabolite target protein database (TPDB) - a web-accessible resource

Background: The toxic effects of many simple organic compounds stem from their biotransformation to chemically reactive metabolites which bind covalently to cellular proteins. To understand the mechanisms of cytotoxic responses it may be important to know which proteins become adducted and whether some may be common targets of multiple toxins. The literature of this field is widely scattered but expanding rapidly, suggesting the need for a comprehensive, searchable database of reactive metabolite target proteins. Description: The Reactive Metabolite Target Protein Database (TPDB) is a comprehensive, curated, searchable, documented compilation of publicly available information on the protein targets of reactive metabolites of 18 well-studied chemicals and drugs of known toxicity. TPDB software enables i) string searches for author names and proteins names/synonyms, ii) more complex searches by selecting chemical compound, animal species, target tissue and protein names/ synonyms from p...

• Type: Journal
• Year: 2007
• Where: BMCBI
• Authors: Robert P. Hanzlik, Yakov M. Koen, Bhargav Theertham, Yinghua Dong, Jianwen Fang
• Keywords: BMCBI 2007, Protein, Reactive Metabolite, Reactive Metabolite Target