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PSB
2004
13 years 9 months ago
Phylogenetic Motif Detection by Expectation-Maximization on Evolutionary Mixtures
ct The preferential conservation of transcription factor binding sites implies that non-coding sequence data from related species will prove a powerful asset to motif discovery. We...
Alan M. Moses, Derek Y. Chiang, Michael B. Eisen
BMCBI
2007
136views more  BMCBI 2007»
13 years 7 months ago
Prediction of tissue-specific cis-regulatory modules using Bayesian networks and regression trees
Background: In vertebrates, a large part of gene transcriptional regulation is operated by cisregulatory modules. These modules are believed to be regulating much of the tissue-sp...
Xiaoyu Chen, Mathieu Blanchette
RECOMB
2004
Springer
14 years 28 days ago
Application of Kernel Method to Reveal Subtypes of TF Binding Motifs
Transcription factor binding sites often contain several subtypes of sequences that follow not just one but several different patterns. We developed a novel sensitive method based ...
Alexander E. Kel, Yuri Tikunov, Nico Voss, Jü...
BMCBI
2011
12 years 11 months ago
Reconstructing genome-wide regulatory network of E. coli using transcriptome data and predicted transcription factor activities
Background: Gene regulatory networks play essential roles in living organisms to control growth, keep internal metabolism running and respond to external environmental changes. Un...
Yao Fu, Laura R. Jarboe, Julie A. Dickerson
TCS
2008
13 years 7 months ago
Detection of subtle variations as consensus motifs
We address the problem of detecting consensus motifs, that occur with subtle variations, across multiple sequences. These are usually functional domains in DNA sequences such as t...
Matteo Comin, Laxmi Parida