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» Empirical Bayes analysis of single nucleotide polymorphisms
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BMCBI
2011
12 years 11 months ago
Inference of Chromosome-Specific Copy Numbers Using Population Haplotypes
Background: Using microarray and sequencing platforms, a large number of copy number variations (CNVs) have been identified in humans. In practice, because our human genome is a d...
Yao-Ting Huang, Min-Han Wu
RECOMB
2009
Springer
14 years 8 months ago
COE: A General Approach for Efficient Genome-Wide Two-Locus Epistasis Test in Disease Association Study
The availability of high density single nucleotide polymorphisms (SNPs) data has made genome-wide association study computationally challenging. Twolocus epistasis (gene-gene inter...
Xiang Zhang, Feng Pan, Yuying Xie, Fei Zou, Wei Wa...
ISBI
2011
IEEE
12 years 11 months ago
Principal components regression: Multivariate, gene-based tests in imaging genomics
In imaging genomics, there have been rapid advances in genome-wide, image-wide searches for genes that influence brain structure. Most efforts focus on univariate tests that treat...
Derrek P. Hibar, Jason L. Stein, Omid Kohannim, Ne...
ISBI
2011
IEEE
12 years 11 months ago
Hierarchical clustering of the genetic connectivity matrix reveals the network topology of gene action on brain microstructure:
Genetic correlation (rg) analysis determines how much of the correlation between two measures is due to common genetic influences. In an analysis of 4 Tesla diffusion tensor image...
Ming-Chang Chiang, Marina Barysheva, Katie McMahon...
BMCBI
2010
162views more  BMCBI 2010»
13 years 7 months ago
SNP-RFLPing 2: an updated and integrated PCR-RFLP tool for SNP genotyping
Background: PCR-restriction fragment length polymorphism (RFLP) assay is a cost-effective method for SNP genotyping and mutation detection, but the manual mining for restriction e...
Hsueh-Wei Chang, Yu-Huei Cheng, Li-Yeh Chuang, Che...