Background: Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper ...
Background: We consider the problem of parameter estimation (model calibration) in nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and multi-m...
Maria Rodriguez-Fernandez, Jose A. Egea, Julio R. ...
For every string inclusion relation there are two optimization problems: find a longest string included in every string of a given finite language, and find a shortest string in...
Background: Several supervised and unsupervised learning tools are available to classify functional genomics data. However, relatively less attention has been given to exploratory...
We describe a software system, TOPO, that numerically analyzes and graphically displays topological aspects of a three dimensional vector field, v, to produce a single, relativel...