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BMCBI
2007
13 years 7 months ago
2007
Background: In order to recapitulate tumor progression pathways using epigenetic data, we developed novel clustering and pathway reconstruction algorithms, collectively referred t...
BIOINFORMATICS
2010
13 years 7 months ago
2010
Motivation: Tumorigenesis is an evolutionary process by which tumor cells acquire sequences of mutations leading to increased growth, invasiveness, and eventually metastasis. It i...
BMCBI
2008
13 years 7 months ago
2008
Background: There is accumulating evidence that the milieu of repeat elements and other nongenic sequence features at a given chromosomal locus, here defined as the genome environ...
BMCBI
2008
13 years 7 months ago
2008
Background: Transcription factors (TFs) are core functional proteins which play important roles in gene expression control, and they are key factors for gene regulation network co...
BMCBI
2008
13 years 7 months ago
2008
Background: Analysis of sequence composition is a routine task in genome research. Organisms are characterized by their base composition, dinucleotide relative abundance, codon us...