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BMCBI
2006
101views more  BMCBI 2006»
13 years 9 months ago
SynTReN: a generator of synthetic gene expression data for design and analysis of structure learning algorithms
Background: The development of algorithms to infer the structure of gene regulatory networks based on expression data is an important subject in bioinformatics research. Validatio...
Tim Van den Bulcke, Koen Van Leemput, Bart Naudts,...
BMCBI
2008
125views more  BMCBI 2008»
13 years 9 months ago
SynteBase/SynteView: a tool to visualize gene order conservation in prokaryotic genomes
Background: It has been repeatedly observed that gene order is rapidly lost in prokaryotic genomes. However, persistent synteny blocks are found when comparing more or less distan...
Frédéric Lemoine, Bernard Labedan, O...
BMCBI
2010
97views more  BMCBI 2010»
13 years 6 months ago
Preprocessing of gene expression data by optimally robust estimators
Background: The preprocessing of gene expression data obtained from several platforms routinely includes the aggregation of multiple raw signal intensities to one expression value...
Matthias Kohl, Hans-Peter Deigner
JBI
2004
171views Bioinformatics» more  JBI 2004»
13 years 10 months ago
Consensus Clustering and Functional Interpretation of Gene Expression Data
Microarray analysis using clustering algorithms can suffer from lack of inter-method consistency in assigning related gene-expression profiles to clusters. Obtaining a consensus s...
Paul Kellam, Stephen Swift, Allan Tucker, Veronica...
APBC
2004
107views Bioinformatics» more  APBC 2004»
13 years 10 months ago
An Empirical Bayes Adjustment to Multiple p-values for the Detection of Differentially Expressed Genes in Microarray Experiments
In recent microarray experiments thousands of gene expressions are simultaneously tested in comparing samples (e.g., tissue types or experimental conditions). Application of a sta...
Somnath Datta, Susmita Datta