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BMCBI
2010
113views more  BMCBI 2010»
13 years 7 months ago
Unifying generative and discriminative learning principles
Background: The recognition of functional binding sites in genomic DNA remains one of the fundamental challenges of genome research. During the last decades, a plethora of differe...
Jens Keilwagen, Jan Grau, Stefan Posch, Marc Stric...
BMCBI
2007
164views more  BMCBI 2007»
13 years 7 months ago
SEARCHPATTOOL: a new method for mining the most specific frequent patterns for binding sites with application to prokaryotic DNA
Background: Computational methods to predict transcription factor binding sites (TFBS) based on exhaustive algorithms are guaranteed to find the best patterns but are often limite...
Fathi Elloumi, Martha Nason
BMCBI
2007
148views more  BMCBI 2007»
13 years 7 months ago
fREDUCE: Detection of degenerate regulatory elements using correlation with expression
Background: The precision of transcriptional regulation is made possible by the specificity of physical interactions between transcription factors and their cognate binding sites ...
Randy Z. Wu, Christina Chaivorapol, Jiashun Zheng,...
BMCBI
2006
127views more  BMCBI 2006»
13 years 7 months ago
Using local gene expression similarities to discover regulatory binding site modules
Background: We present an approach designed to identify gene regulation patterns using sequence and expression data collected for Saccharomyces cerevisae. Our main goal is to rela...
Bartek Wilczynski, Torgeir R. Hvidsten, Andriy Kry...
APBC
2004
116views Bioinformatics» more  APBC 2004»
13 years 9 months ago
Structure-Function Relationship in DNA Sequence Recognition by Transcription Factors
Transcription factors play essential role in the gene regulation in higher organisms, binding to multiple target sequences and regulating multiple genes in a complex manner. In or...
Akinori Sarai, Samuel Selvaraj, M. Michael Gromiha...