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BMCBI
2005
124views more  BMCBI 2005»
13 years 7 months ago
Probabilistic annotation of protein sequences based on functional classifications
: One of the most evident achievements of bioinformatics is the development of methods that transfer biological knowledge from characterised proteins to uncharacterised sequences. ...
Emmanuel D. Levy, Christos A. Ouzounis, Walter R. ...
BMCBI
2010
189views more  BMCBI 2010»
13 years 7 months ago
High quality protein sequence alignment by combining structural profile prediction and profile alignment using SABERTOOTH
Background: Protein alignments are an essential tool for many bioinformatics analyses. While sequence alignments are accurate for proteins of high sequence similarity, they become...
Florian Teichert, Jonas Minning, Ugo Bastolla, Mar...
BMCBI
2007
115views more  BMCBI 2007»
13 years 7 months ago
Local comparison of protein structures highlights cases of convergent evolution in analogous functional sites
Background: We performed an exhaustive search for local structural similarities in an ensemble of non-redundant protein functional sites. With the purpose of finding new examples ...
Gabriele Ausiello, Daniele Peluso, Allegra Via, Ma...
BMCBI
2008
134views more  BMCBI 2008»
13 years 7 months ago
Identification of transcription factor contexts in literature using machine learning approaches
Background: Availability of information about transcription factors (TFs) is crucial for genome biology, as TFs play a central role in the regulation of gene expression. While man...
Hui Yang, Goran Nenadic, John A. Keane
BMCBI
2008
160views more  BMCBI 2008»
13 years 7 months ago
A comparison of four clustering methods for brain expression microarray data
Background: DNA microarrays, which determine the expression levels of tens of thousands of genes from a sample, are an important research tool. However, the volume of data they pr...
Alexander L. Richards, Peter Holmans, Michael C. O...