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BMCBI
2007
148views more  BMCBI 2007»
13 years 10 months ago
fREDUCE: Detection of degenerate regulatory elements using correlation with expression
Background: The precision of transcriptional regulation is made possible by the specificity of physical interactions between transcription factors and their cognate binding sites ...
Randy Z. Wu, Christina Chaivorapol, Jiashun Zheng,...
BIODATAMINING
2008
163views more  BIODATAMINING 2008»
13 years 10 months ago
Multivariate profiling of neurodegeneration-associated changes in a subcellular compartment of neurons via image processing
Background: Dysfunction in the endolysosome, a late endosomal to lysosomal degradative intracellular compartment, is an early hallmark of some neurodegenerative diseases, in parti...
Saravana K. Kumarasamy, Yunshi Wang, Vignesh Viswa...
BMCBI
2010
108views more  BMCBI 2010»
13 years 10 months ago
Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of h
Background: A major goal of the analysis of high-dimensional RNA expression data from tumor tissue is to identify prognostic signatures for discriminating patient subgroups. For t...
Birte Hellwig, Jan G. Hengstler, Marcus Schmidt, M...
BMCBI
2010
128views more  BMCBI 2010»
13 years 10 months ago
Conserved residue clusters at protein-protein interfaces and their use in binding site identification
Background: Biological evolution conserves protein residues that are important for structure and function. Both protein stability and function often require a certain degree of st...
Mainak Guharoy, Pinak Chakrabarti
CVPR
2006
IEEE
15 years 4 days ago
Shape-Based Approach to Robust Image Segmentation using Kernel PCA
Segmentation involves separating an object from the background. In this work, we propose a novel segmentation method combining image information with prior shape knowledge, within...
Samuel Dambreville, Yogesh Rathi, Allen Tannenbaum