We introduce a new technique to solve exactly a discrete optimization problem, based on the paradigm of “negative” thinking. The motivation is that when searching the space of...
Evguenii I. Goldberg, Luca P. Carloni, Tiziano Vil...
This paper describes Shasta, a system that supports a shared address space in software on clusters of computers with physically distributed memory. A unique aspect of Shasta compa...
Daniel J. Scales, Kourosh Gharachorloo, Chandramoh...
Background: The availability of complete genomic sequences for hundreds of organisms promises to make obtaining genome-wide estimates of substitution rates, selective constraints ...
Amy Egan, Anup Mahurkar, Jonathan Crabtree, Jonath...
Background: Biologically active sequence motifs often have positional preferences with respect to a genomic landmark. For example, many known transcription factor binding sites (T...
Nak-Kyeong Kim, Kannan Tharakaraman, Leonardo Mari...
Background: In proteomics experiments, database-search programs are the method of choice for protein identification from tandem mass spectra. As amino acid sequence databases grow...
Jason W. H. Wong, Matthew J. Sullivan, Hugh M. Car...