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» Gene set analysis for longitudinal gene expression data
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BCB
2010
175views Bioinformatics» more  BCB 2010»
13 years 3 months ago
Gene set analysis using principal components
We present a new method for identifying gene sets associated with labeled samples, where the labels can be case versus control, or genotype differences. Existing approaches to thi...
Isa Kemal Pakatci, Wei Wang, Leonard McMillan
NAR
2011
248views Computer Vision» more  NAR 2011»
12 years 11 months ago
NCBI GEO: archive for functional genomics data sets - 10 years on
A decade ago, the Gene Expression Omnibus (GEO) database was established at the National Center for Biotechnology Information (NCBI). The original objective of GEO was to serve as...
Tanya Barrett, Dennis B. Troup, Stephen E. Wilhite...
BMCBI
2010
154views more  BMCBI 2010»
13 years 6 months ago
Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation
Background: External stimulations of cells by hormones, cytokines or growth factors activate signal transduction pathways that subsequently induce a re-arrangement of cellular gen...
Andreas Kowarsch, Florian Blöchl, Sebastian B...
ITA
2006
167views Communications» more  ITA 2006»
13 years 8 months ago
Characterization of lung tumor subtypes through gene expression cluster validity assessment
The problem of assessing the reliability of clusters patients identified by clustering algorithms is crucial to estimate the significance of subclasses of diseases detectable at b...
Giorgio Valentini, Francesca Ruffino
BMCBI
2002
89views more  BMCBI 2002»
13 years 8 months ago
Sources of variability and effect of experimental approach on expression profiling data interpretation
Background: We provide a systematic study of the sources of variability in expression profiling data using 56 RNAs isolated from human muscle biopsies (34 Affymetrix MuscleChip ar...
Marina Bakay, Yi-Wen Chen, Rehannah H. A. Borup, P...