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BMCBI
2010
115views more  BMCBI 2010»
13 years 9 months ago
Importance of replication in analyzing time-series gene expression data: Corticosteroid dynamics and circadian patterns in rat l
Background: Microarray technology is a powerful and widely accepted experimental technique in molecular biology that allows studying genome wide transcriptional responses. However...
Tung T. Nguyen, Richard R. Almon, Debra C. DuBois,...
SCAM
2007
IEEE
14 years 3 months ago
Finding Inputs that Reach a Target Expression
We present an automated program analysis, called Reach, to compute program inputs that cause evaluation of explicitly-marked target expressions. Reach has a range of applications ...
Matthew Naylor, Colin Runciman
BMCBI
2007
146views more  BMCBI 2007»
13 years 9 months ago
Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data
Background: Transcriptional modules (TM) consist of groups of co-regulated genes and transcription factors (TF) regulating their expression. Two high-throughput (HT) experimental ...
Xiangdong Liu, Walter J. Jessen, Siva Sivaganesan,...
BMCBI
2008
125views more  BMCBI 2008»
13 years 9 months ago
SNPLims: a data management system for genome wide association studies
Background: Recent progresses in genotyping technologies allow the generation high-density genetic maps using hundreds of thousands of genetic markers for each DNA sample. The ava...
Alessandro Orro, Guia Guffanti, Erika Salvi, Fabio...
CCS
2009
ACM
14 years 3 months ago
Learning your identity and disease from research papers: information leaks in genome wide association study
Genome-wide association studies (GWAS) aim at discovering the association between genetic variations, particularly single-nucleotide polymorphism (SNP), and common diseases, which...
Rui Wang, Yong Fuga Li, XiaoFeng Wang, Haixu Tang,...