There is a pressing need to align growing set of expressed sequence tags (ESTs) to newly sequenced human genome. The problem is, however, complicated by the exon/intron structure ...
We demonstrate how Field Programmable Gate Arrays (FPGAs) may be used to address the computing challenges associated with assembling genome sequences from recent ultra-high-through...
Kristian Stevens, Henry Chen, Terry Filiba, Peter ...
Abstract. Single nucleotide polymorphisms (SNPs) are the most frequent form of human genetic variation. They are of fundamental importance for a variety of applications including m...
Giuseppe Lancia, Vineet Bafna, Sorin Istrail, Ross...
Hierarchical genome assembly can be divided into three distinct stages: sequencing and assembling shotgun reads for each of a series of selected BAC clones; assembling the resulti...
Daolong Wang, Mario Lauria, Bo Yuan, Fred A. Wrigh...
Background: High throughput sequencing (HTS) platforms produce gigabases of short read (<100 bp) data per run. While these short reads are adequate for resequencing application...
Adel Dayarian, Todd P. Michael, Anirvan M. Sengupt...