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» Goal-oriented Analysis of Regulations
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BIB
2010
147views more  BIB 2010»
15 years 4 months ago
Toward the dynamic interactome: it's about time
Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms.The availability of experimentally determined large-scale cellular networks...
Teresa M. Przytycka, Mona Singh, Donna K. Slonim
BMCBI
2010
154views more  BMCBI 2010»
15 years 1 months ago
Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation
Background: External stimulations of cells by hormones, cytokines or growth factors activate signal transduction pathways that subsequently induce a re-arrangement of cellular gen...
Andreas Kowarsch, Florian Blöchl, Sebastian B...
139
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BMCBI
2006
119views more  BMCBI 2006»
15 years 4 months ago
Evaluation of microarray data normalization procedures using spike-in experiments
Background: Recently, a large number of methods for the analysis of microarray data have been proposed but there are few comparisons of their relative performances. By using so-ca...
Patrik Rydén, Henrik Andersson, Mattias Lan...
BMCBI
2007
147views more  BMCBI 2007»
15 years 4 months ago
Predicting combinatorial binding of transcription factors to regulatory elements in the human genome by association rule mining
Background: Cis-acting transcriptional regulatory elements in mammalian genomes typically contain specific combinations of binding sites for various transcription factors. Althoug...
Xochitl C. Morgan, Shulin Ni, Daniel P. Miranker, ...
BMCBI
2010
240views more  BMCBI 2010»
15 years 4 months ago
CircuitsDB: a database of mixed microRNA/transcription factor feed-forward regulatory circuits in human and mouse
Background: Transcription Factors (TFs) and microRNAs (miRNAs) are key players for gene expression regulation in higher eukaryotes. In the last years, a large amount of bioinforma...
Olivier Friard, Angela Re, Daniela Taverna, Michel...