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BMCBI
2010
176views more  BMCBI 2010»
13 years 8 months ago
TargetSpy: a supervised machine learning approach for microRNA target prediction
Background: Virtually all currently available microRNA target site prediction algorithms require the presence of a (conserved) seed match to the 5' end of the microRNA. Recen...
Martin Sturm, Michael Hackenberg, David Langenberg...
RECOMB
2006
Springer
14 years 9 months ago
Assessing Significance of Connectivity and Conservation in Protein Interaction Networks
Computational and comparative analysis of protein-protein interaction (PPI) networks enable understanding of the modular organization of the cell through identification of functio...
Mehmet Koyutürk, Ananth Grama, Wojciech Szpan...
BMCBI
2006
130views more  BMCBI 2006»
13 years 8 months ago
MicroTar: predicting microRNA targets from RNA duplexes
Background: The accurate prediction of a comprehensive set of messenger RNAs (targets) regulated by animal microRNAs (miRNAs) remains an open problem. In particular, the predictio...
Rahul Thadani, Martti T. Tammi
NAR
2006
59views more  NAR 2006»
13 years 8 months ago
GenDecoder: genetic code prediction for metazoan mitochondria
Although the majority of the organisms use the same genetic code to translate DNA, several variants have been described in a wide range of organisms, both in nuclear and organella...
Federico Abascal, Rafael Zardoya, David Posada
BMCBI
2007
104views more  BMCBI 2007»
13 years 8 months ago
Identification of putative regulatory upstream ORFs in the yeast genome using heuristics and evolutionary conservation
Background: The translational efficiency of an mRNA can be modulated by upstream open reading frames (uORFs) present in certain genes. A uORF can attenuate translation of the main...
Marija Cvijovic, Daniel Dalevi, Elizabeth Bilsland...