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119
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RECOMB
2006
Springer
16 years 2 months ago
A Parsimony Approach to Genome-Wide Ortholog Assignment
The assignment of orthologous genes between a pair of genomes is a fundamental and challenging problem in comparative genomics, since many computational methods for solving various...
Zheng Fu, Xin Chen, Vladimir Vacic, Peng Nan, Yang...
111
Voted
BMCBI
2010
115views more  BMCBI 2010»
15 years 2 months ago
Machine learning methods for metabolic pathway prediction
Background: A key challenge in systems biology is the reconstruction of an organism's metabolic network from its genome sequence. One strategy for addressing this problem is ...
Joseph M. Dale, Liviu Popescu, Peter D. Karp
111
Voted
BMCBI
2005
70views more  BMCBI 2005»
15 years 2 months ago
Integrating alternative splicing detection into gene prediction
Background: Alternative splicing (AS) is now considered as a major actor in transcriptome/ proteome diversity and it cannot be neglected in the annotation process of a new genome....
Sylvain Foissac, Thomas Schiex
136
Voted
GCB
2010
Springer
198views Biometrics» more  GCB 2010»
15 years 18 days ago
RNALfoldz: Efficient Prediction of Thermodynamically Stable, Local Secondary Structures
Abstract: The search for local RNA secondary structures and the annotation of unusually stable folding regions in genomic sequences are two well motivated bioinformatic problems. I...
Andreas R. Gruber, Stephan H. F. Bernhart, You Zho...
101
Voted
NAR
2011
203views Computer Vision» more  NAR 2011»
14 years 5 months ago
ViralZone: a knowledge resource to understand virus diversity
The molecular diversity of viruses complicates the interpretation of viral genomic and proteomic data. To make sense of viral gene functions, investigators must be familiar with t...
Chantal Hulo, Edouard De Castro, Patrick Masson, L...